*,*::before,*::after{box-sizing:border-box;margin:0;padding:0}
:root{
  --navy:#0d2240; --navy-2:#11294c; --blue:#2563b0; --blue-d:#1b4d8f;
  --teal:#1fb0a6; --teal-d:#138a80;
  --ink:#16203a; --muted:#5d6b82; --muted-2:#8493a8;
  --paper:#ffffff; --mist:#f5f8fc; --lblue:#eaf2fb; --lteal:#e7f6f3;
  --line:#e4eaf2; --line-2:rgba(255,255,255,.12);
  --maxw:1240px; --ease:cubic-bezier(.22,.61,.36,1);
  --shadow:0 30px 70px -34px rgba(13,34,64,.42);
}
html{scroll-behavior:smooth}
body{font-family:'DM Sans',-apple-system,system-ui,sans-serif;color:var(--ink);background:var(--paper);-webkit-font-smoothing:antialiased;line-height:1.6;overflow-x:hidden}
h1,h2,h3,h4{font-family:'DM Serif Display',Georgia,serif;font-weight:400;line-height:1.1;letter-spacing:-.01em}
h1 em,h2 em,h3 em{font-style:italic;color:var(--teal-d)}
a{color:inherit;text-decoration:none}
img{max-width:100%;display:block}
.wrap{max-width:var(--maxw);margin:0 auto;padding:0 32px}
.ey{font-family:'DM Sans';font-size:12px;font-weight:600;letter-spacing:.22em;text-transform:uppercase;color:var(--teal-d)}
.reveal{opacity:0;transform:translateY(26px);transition:opacity .9s var(--ease),transform .9s var(--ease)}
.reveal.in{opacity:1;transform:none}
.btn{display:inline-flex;align-items:center;gap:9px;font-family:'DM Sans';font-weight:600;font-size:15px;padding:14px 26px;border-radius:8px;transition:transform .3s var(--ease),box-shadow .3s,background .3s,color .3s;cursor:pointer;border:0}
.btn-pri{background:var(--blue);color:#fff;box-shadow:0 10px 26px -8px rgba(37,99,176,.55)}
.btn-pri:hover{transform:translateY(-2px);background:var(--blue-d);box-shadow:0 16px 34px -10px rgba(37,99,176,.6)}
.btn-ghost{border:1.5px solid var(--line);color:var(--ink);background:#fff}
.btn-ghost:hover{border-color:var(--blue);color:var(--blue)}
.btn-teal{background:var(--teal);color:#04231f}
.btn-teal:hover{transform:translateY(-2px);background:var(--teal-d);color:#fff}
.btn-light{background:#fff;color:var(--navy)}
.btn-light:hover{transform:translateY(-2px)}

/* ANNOUNCEMENT BAR */
.topbar{position:fixed;top:0;left:0;right:0;z-index:101;background:linear-gradient(90deg,var(--teal-d),var(--blue-d));color:#fff;font-size:13px;text-align:center;transition:transform .4s var(--ease)}
.topbar.hide{transform:translateY(-100%)}
.topbar a{display:block;padding:9px 16px;font-weight:500;letter-spacing:.01em}
.topbar b{font-weight:700}
.topbar .ar{opacity:.85;transition:transform .3s}
.topbar a:hover .ar{transform:translateX(4px)}

/* NAV */
header{position:fixed;left:0;right:0;top:var(--topbar-height,36px);z-index:100;transition:top .4s var(--ease),background .4s var(--ease),box-shadow .4s,border-color .4s;border-bottom:1px solid transparent}
header.scrolled{top:0;background:rgba(255,255,255,.92);backdrop-filter:saturate(160%) blur(14px);border-bottom:1px solid var(--line);box-shadow:0 6px 24px -18px rgba(13,34,64,.4)}
.nav{display:flex;align-items:center;justify-content:space-between;height:80px}
.nav .logo img{height:32px;width:auto;transition:filter .4s}
header:not(.scrolled) .nav .logo img{filter:brightness(0) invert(1)}
.navl{display:flex;align-items:center;gap:34px;list-style:none}
.navl a{font-size:15px;font-weight:500;color:#fff;transition:color .25s,opacity .25s;position:relative;opacity:.85}
.navl a:hover{opacity:1}
header.scrolled .navl a{color:#33415a;opacity:1}
header.scrolled .navl a:hover{color:var(--blue)}
.navl a::after{content:"";position:absolute;left:0;right:100%;bottom:-6px;height:2px;background:var(--teal);transition:right .3s var(--ease)}
.navl a:hover::after{right:0}
.navcta{padding:11px 22px;font-size:14px}
header:not(.scrolled) .navcta{background:rgba(255,255,255,.12);border:1px solid rgba(255,255,255,.35);color:#fff;backdrop-filter:blur(6px)}
header:not(.scrolled) .navcta:hover{background:rgba(255,255,255,.22)}
.navtoggle{display:none;background:none;border:0;font-size:26px;color:#fff;cursor:pointer}
header.scrolled .navtoggle{color:var(--navy)}

/* HERO — cinematic dark */
.hero{position:relative;min-height:100vh;display:flex;align-items:center;padding:150px 0 120px;overflow:hidden;background:var(--navy)}
html.cap .hero{min-height:760px}
.hero-bg{position:absolute;inset:0;z-index:0}
.hero-bg img{position:absolute;top:-9%;left:0;width:100%;height:118%;object-fit:cover;object-position:90% center;will-change:transform}
.hero-bg::after{content:"";position:absolute;inset:0;background:
  linear-gradient(95deg,rgba(10,22,40,.86) 0%,rgba(10,22,40,.58) 38%,rgba(10,22,40,.3) 66%,rgba(10,22,40,.1) 100%),
  radial-gradient(120% 100% at 100% 50%,transparent 36%,rgba(8,22,44,.55) 100%)}
.hero-inner{position:relative;z-index:2;width:100%;max-width:600px}
.hero h1,.hero .lede{text-shadow:0 2px 26px rgba(5,14,28,.55)}
.hero .ey{color:var(--teal);opacity:.95}
.hero h1{font-size:clamp(42px,6vw,80px);margin:22px 0 0;letter-spacing:-.02em;color:#fff}
.hero h1 em{color:var(--teal)}
.hero .lede{font-size:clamp(17px,1.5vw,21px);color:#c4d2e4;max-width:46ch;margin:26px 0 36px;font-weight:300}
.hero-cta{display:flex;gap:14px;flex-wrap:wrap}
.hero .btn-ghost{background:rgba(255,255,255,.06);border-color:rgba(255,255,255,.3);color:#fff}
.hero .btn-ghost:hover{background:rgba(255,255,255,.13);border-color:#fff;color:#fff}
.pills{display:flex;flex-wrap:wrap;gap:10px;margin-top:40px}
.pill{font-size:13px;font-weight:500;color:#dce7f3;background:rgba(255,255,255,.06);border:1px solid rgba(255,255,255,.16);padding:9px 15px;border-radius:100px;display:flex;align-items:center;gap:8px;backdrop-filter:blur(6px)}
.pill i{width:7px;height:7px;border-radius:50%;background:var(--teal);box-shadow:0 0 10px var(--teal)}
.scrollcue{position:absolute;bottom:34px;left:50%;transform:translateX(-50%);z-index:2;font-size:10.5px;letter-spacing:.24em;text-transform:uppercase;color:rgba(255,255,255,.5);display:flex;flex-direction:column;align-items:center;gap:10px}
.scrollcue i{width:1px;height:44px;background:linear-gradient(var(--teal),transparent);animation:cue 2.4s var(--ease) infinite}
@keyframes cue{0%{transform:scaleY(0);transform-origin:top}45%{transform:scaleY(1);transform-origin:top}55%{transform:scaleY(1);transform-origin:bottom}100%{transform:scaleY(0);transform-origin:bottom}}

/* CREDIBILITY STRIP */
.cred{background:var(--paper);border-bottom:1px solid var(--line)}
.cred .row{display:flex;align-items:center;justify-content:space-between;gap:24px;padding:26px 0;flex-wrap:wrap}
.cred .lab{font-size:11.5px;letter-spacing:.18em;text-transform:uppercase;color:var(--muted-2);font-weight:600;white-space:nowrap}
.cred .marks{display:flex;align-items:center;gap:34px;flex-wrap:wrap}
.cred .marks span{font-family:'DM Serif Display';font-size:18px;color:#3a4a63;letter-spacing:.01em;opacity:.85}

/* STAT BAND */
.stats{background:linear-gradient(120deg,var(--navy),var(--navy-2));color:#fff}
.stats .grid{display:grid;grid-template-columns:repeat(4,1fr)}
.stat{padding:54px 34px;border-right:1px solid var(--line-2)}
.stat:last-child{border-right:0}
.stat b{font-family:'DM Serif Display';font-size:42px;line-height:1;display:block;letter-spacing:-.01em}
.stat b span{color:var(--teal)}
.stat .k{margin-top:14px;font-size:14px;color:#aebccf;font-weight:500}
.stat .s{font-size:12.5px;color:#7d90a8;margin-top:3px}

/* SECTION */
.sec{padding:120px 0}
.sec-head{max-width:760px}
.sec-head h2{font-size:clamp(30px,3.8vw,48px);margin-top:16px}
.sec-head p{margin-top:20px;font-size:18px;color:var(--muted)}

/* SCIENCE */
.science{background:var(--paper)}
.sci-grid{display:grid;grid-template-columns:1fr 1fr;gap:64px;align-items:center;margin-top:8px}
.sci-copy h2{font-size:clamp(28px,3.4vw,42px);margin-top:16px}
.sci-copy p{color:var(--muted);font-size:17px;margin-top:20px}
.sci-list{margin:28px 0 30px;list-style:none;display:grid;gap:14px}
.sci-list li{display:flex;gap:14px;align-items:flex-start;font-size:15.5px;color:var(--ink)}
.sci-list li::before{content:"";flex:0 0 22px;height:22px;border-radius:6px;background:var(--lteal);background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='14' height='14' viewBox='0 0 24 24' fill='none' stroke='%23138a80' stroke-width='3' stroke-linecap='round' stroke-linejoin='round'%3E%3Cpath d='M20 6 9 17l-5-5'/%3E%3C/svg%3E");background-repeat:no-repeat;background-position:center;margin-top:1px}
.figcard{position:relative;border-radius:20px;overflow:hidden;border:1px solid var(--line);background:#fff;box-shadow:var(--shadow)}
.figcard img{width:100%}
.figcap{padding:16px 22px;border-top:1px solid var(--line);font-size:13px;color:var(--muted);display:flex;justify-content:space-between;gap:12px;align-items:center}
.figcap b{font-family:'DM Sans';font-weight:600;color:var(--navy)}
.tagchip{background:var(--lblue);color:var(--blue-d);font-size:11.5px;font-weight:600;padding:5px 11px;border-radius:100px;white-space:nowrap}

/* CLINICAL */
.clinical{background:linear-gradient(160deg,var(--navy),#0a1c38);color:#fff;position:relative;overflow:hidden}
.clinical::before{content:"";position:absolute;width:620px;height:620px;border-radius:50%;background:radial-gradient(circle,rgba(31,176,166,.18),transparent 70%);right:-160px;top:-160px}
.clinical .wrap{position:relative;z-index:2}
.cl-grid{display:grid;grid-template-columns:1fr 1fr;gap:60px;align-items:center}
.cl-copy h2{font-size:clamp(30px,3.6vw,46px);margin-top:16px;color:#fff}
.cl-copy h2 em{color:var(--teal)}
.cl-copy p{color:#b3c2d6;font-size:17px;margin-top:20px}
.cl-stats{display:grid;grid-template-columns:1fr 1fr;gap:14px;margin:32px 0}
.clstat{border:1px solid var(--line-2);border-radius:14px;padding:22px;background:rgba(255,255,255,.03)}
.clstat b{font-family:'DM Serif Display';font-size:34px;color:#fff;line-height:1;display:block}
.clstat b span{color:var(--teal)}
.clstat .k{font-size:13.5px;color:#9fb0c6;margin-top:8px}
.cl-meta{display:flex;flex-wrap:wrap;gap:10px;margin-top:6px}
.cl-meta span{font-size:12.5px;color:#cdd9e8;border:1px solid var(--line-2);padding:7px 13px;border-radius:100px}
.cl-figure{border-radius:18px;overflow:hidden;border:1px solid var(--line-2);background:#0c213f;box-shadow:0 40px 80px -30px rgba(0,0,0,.6)}
.cl-figure img{width:100%}
.cl-figure .cap{padding:14px 20px;font-size:12.5px;color:#9fb0c6;border-top:1px solid var(--line-2);background:rgba(255,255,255,.02)}

/* PIPELINE TEASER */
.pipe{background:var(--mist)}
.ptable{margin-top:54px;border:1px solid var(--line);border-radius:18px;overflow:hidden;background:#fff;box-shadow:var(--shadow)}
.prow{display:grid;grid-template-columns:1.3fr 1fr .9fr 2.4fr;align-items:center;border-bottom:1px solid var(--line)}
.prow:last-child{border-bottom:0}
.prow.head{background:var(--navy);color:#fff}
.prow.head div{font-size:11.5px;letter-spacing:.14em;text-transform:uppercase;font-weight:600;color:#aebccf;padding:18px 24px}
.prow .cell{padding:24px 24px;font-size:15px}
.prow .ind b{font-family:'DM Serif Display';font-size:19px;display:block;color:var(--ink)}
.prow .ind em{font-style:normal;color:var(--muted);font-size:13px}
.prow .area{font-weight:600;color:var(--blue-d)}
.prow .stage{font-size:13.5px;color:var(--muted)}
.bar{position:relative;height:9px;border-radius:100px;background:var(--line)}
.bar i{position:absolute;inset:0 auto 0 0;border-radius:100px;background:linear-gradient(90deg,var(--blue),var(--teal));width:0;transition:width 1.3s var(--ease)}
.barlabels{display:grid;grid-template-columns:repeat(4,1fr);margin-top:8px;font-size:10.5px;color:var(--muted-2);letter-spacing:.03em}

/* CTA */
.cta{background:linear-gradient(120deg,var(--blue),var(--teal-d));color:#fff;text-align:center}
.cta h2{font-size:clamp(30px,4vw,52px);max-width:20ch;margin:0 auto;color:#fff}
.cta p{max-width:54ch;margin:20px auto 34px;font-size:18px;color:#e7f1fb}
.cta .row{display:flex;gap:14px;justify-content:center;flex-wrap:wrap}

/* FOOTER */
footer{background:#081a33;color:#9fb0c6;padding:78px 0 38px}
.foot-grid{display:grid;grid-template-columns:1.7fr 1fr 1fr 1.1fr;gap:42px}
.foot-brand img{height:64px;width:auto;margin-bottom:20px;filter:brightness(0) invert(1)}
.foot-brand p{font-size:14px;max-width:32ch;color:#8a9cb4}
.foot-col h5{font-family:'DM Sans';font-size:12px;letter-spacing:.16em;text-transform:uppercase;color:var(--teal);font-weight:600;margin-bottom:18px}
.foot-col a{display:block;font-size:14.5px;margin-bottom:12px;color:#b3c2d6;transition:color .25s}
.foot-col a:hover{color:#fff}
.foot-bottom{margin-top:56px;padding-top:26px;border-top:1px solid rgba(255,255,255,.1);display:flex;justify-content:space-between;flex-wrap:wrap;gap:14px;font-size:13px;color:#73869f}

@media(max-width:960px){
  .navl{display:none}.navtoggle{display:block}
  .navl.open{display:flex;position:fixed;top:calc(var(--topbar-height,36px) + 72px);left:20px;right:20px;align-items:stretch;flex-direction:column;gap:0;background:#fff;padding:10px;border:1px solid var(--line);border-radius:14px;box-shadow:0 24px 70px -24px rgba(13,34,64,.55);max-height:calc(100dvh - var(--topbar-height,36px) - 92px);overflow-y:auto}
  header.scrolled .navl.open{top:72px}
  .navl.open a,.navl.open a.cur{color:#33415a!important;opacity:1;padding:12px 14px;border-radius:8px}
  .navl.open a:hover,.navl.open a.cur{color:var(--blue)!important;background:var(--mist)}
  .navl.open a::after{display:none}
  body.menu-open{overflow:hidden}
  .hero-grid,.sci-grid,.cl-grid{grid-template-columns:1fr;gap:44px}
  .hero{padding-top:130px}.hero-figure{max-width:440px;margin:0 auto}
  .stats .grid{grid-template-columns:1fr 1fr}.stat:nth-child(2n){border-right:0}
  .foot-grid{grid-template-columns:1fr 1fr}
  .prow,.prow.head{grid-template-columns:1.3fr 1fr 2.2fr}
  .prow .stage,.prow.head div:nth-child(3){display:none}
}
@media(max-width:560px){
  .wrap{padding:0 20px}.sec{padding:80px 0}.hero{padding-top:150px}
  .nav{height:72px}.nav .logo img{height:28px}.navcta{display:none}
  .navl.open{top:calc(var(--topbar-height,36px) + 64px)}
  header.scrolled .navl.open{top:64px}
  .stats .grid{grid-template-columns:1fr}.stat{border-right:0}
  .cl-stats{grid-template-columns:1fr}.foot-grid{grid-template-columns:1fr}
  .prow,.prow.head{grid-template-columns:1.4fr 2fr}.prow .area,.prow.head div:nth-child(2){display:none}
  .cred .row{flex-direction:column;justify-content:center;gap:18px;padding:30px 0;text-align:center}
  .cred .lab{white-space:normal}
  .cred .marks{display:grid;grid-template-columns:1fr 1fr;gap:0;width:100%;border:1px solid var(--line);border-radius:12px;overflow:hidden}
  .cred .marks span{font-size:16px;opacity:1;padding:16px 10px;text-align:center;border-bottom:1px solid var(--line);border-right:1px solid var(--line)}
  .cred .marks span:nth-child(2n){border-right:0}
  .cred .marks span:nth-child(5){grid-column:1/-1;border-right:0;border-bottom:0}
  .cred .marks span:nth-child(4){border-bottom:0}
}

/* ============ INNER-PAGE COMPONENTS ============ */
/* Page hero (shorter, dark cinematic) */
.phero{position:relative;padding:190px 0 96px;background:var(--navy);overflow:hidden}
.phero .phero-bg{position:absolute;inset:0;z-index:0;opacity:.6;overflow:hidden}
.phero .phero-bg img{position:absolute;top:-10%;left:0;width:100%;height:120%;object-fit:cover;object-position:center;will-change:transform}
@media(prefers-reduced-motion:reduce){.hero-bg img,.phero-bg img{transform:none!important}}
.phero::after{content:"";position:absolute;inset:0;z-index:1;background:linear-gradient(180deg,rgba(10,22,40,.5) 0%,rgba(10,22,40,.66) 60%,rgba(10,22,40,.86) 100%),radial-gradient(90% 70% at 78% 8%,rgba(31,176,166,.16),transparent 60%)}
.phero .wrap{position:relative;z-index:2}
.phero .ey{color:var(--teal)}
.phero h1{font-size:clamp(38px,5vw,64px);color:#fff;margin-top:18px;max-width:18ch;letter-spacing:-.02em}
.phero h1 em{color:var(--teal)}
.phero p{color:#c4d2e4;font-size:clamp(16px,1.4vw,20px);max-width:60ch;margin-top:22px;font-weight:300}
.phero .hero-cta{display:flex;gap:14px;flex-wrap:wrap;margin-top:32px}
.phero .btn-ghost{background:rgba(255,255,255,.06);border-color:rgba(255,255,255,.3);color:#fff}
.phero .btn-ghost:hover{background:rgba(255,255,255,.13);border-color:#fff;color:#fff}
.breadcrumb{font-size:13px;color:var(--muted-2);margin-bottom:6px;letter-spacing:.02em}
.breadcrumb a:hover{color:var(--teal)}

/* Split feature row (alternating) */
.feature{padding:104px 0}
.feature .split{display:grid;grid-template-columns:1fr 1fr;gap:64px;align-items:center}
.feature.rev .split{direction:rtl}.feature.rev .split>*{direction:ltr}
.feature .tag{display:inline-block;font-size:11.5px;font-weight:600;letter-spacing:.16em;text-transform:uppercase;color:var(--teal-d);background:var(--lteal);padding:7px 13px;border-radius:100px}
.feature h2{font-size:clamp(27px,3.2vw,40px);margin-top:18px}
.feature p{color:var(--muted);font-size:17px;margin-top:18px}
.feature .pull{font-family:'DM Serif Display';font-size:clamp(20px,2vw,25px);color:var(--ink);margin-top:26px;line-height:1.42;font-style:normal;border-left:3px solid var(--teal);padding-left:24px}

/* Definition callout */
.callout{margin-top:26px;border-left:3px solid var(--teal);background:var(--mist);border-radius:0 12px 12px 0;padding:20px 24px}
.callout b{font-family:'DM Sans';font-weight:600;color:var(--navy);display:block;margin-bottom:6px;font-size:14px}
.callout span{color:var(--muted);font-size:15px}

/* 3-step resistance timeline */
.steps{display:grid;grid-template-columns:repeat(3,1fr);gap:18px}
.step{border:1px solid var(--line);border-radius:16px;overflow:hidden;background:#fff;box-shadow:var(--shadow)}
.step .im{aspect-ratio:1/1;overflow:hidden;background:var(--mist)}
.step .im img{width:100%;height:100%;object-fit:cover}
.step .tx{padding:16px 18px}
.step .n{font-size:11px;font-weight:700;letter-spacing:.12em;text-transform:uppercase;color:var(--teal-d)}
.step .t{font-family:'DM Serif Display';font-size:17px;color:var(--ink);margin-top:6px;line-height:1.2}

/* Tumour-type cards */
.tcards{display:grid;grid-template-columns:repeat(4,1fr);gap:20px;margin-top:54px}
.tcard{border:1px solid var(--line);border-radius:16px;padding:28px 24px;background:#fff;transition:transform .4s var(--ease),border-color .4s,box-shadow .4s}
.tcard:hover{transform:translateY(-6px);border-color:var(--teal);box-shadow:var(--shadow)}
.tcard .badge{font-size:11px;font-weight:600;letter-spacing:.1em;text-transform:uppercase;color:var(--blue-d);background:var(--lblue);padding:6px 11px;border-radius:100px;display:inline-block}
.tcard h3{font-size:23px;margin:16px 0 8px}
.tcard p{font-size:14px;color:var(--muted);margin:0}
.tcard.lead{background:linear-gradient(160deg,var(--navy),var(--navy-2));color:#fff;border-color:transparent}
.tcard.lead .badge{background:rgba(31,176,166,.18);color:var(--teal)}
.tcard.lead p{color:#9fb0c6}
.sources{margin-top:30px;font-size:13px;color:var(--muted-2);max-width:80ch}

@media(max-width:960px){
  .feature .split{grid-template-columns:1fr;gap:40px}.feature.rev .split{direction:ltr}
  .tcards{grid-template-columns:1fr 1fr}
  .phero{padding-top:150px}
}
@media(max-width:560px){
  .steps{grid-template-columns:1fr}.tcards{grid-template-columns:1fr}
}

/* ============ TEAM ============ */
.people{display:grid;grid-template-columns:repeat(2,1fr);gap:26px;margin-top:54px}
.person{display:grid;grid-template-columns:150px 1fr;gap:24px;border:1px solid var(--line);border-radius:18px;padding:26px;background:#fff;box-shadow:var(--shadow)}
.person .ph{width:150px;height:150px;border-radius:14px;overflow:hidden;background:linear-gradient(150deg,var(--navy),var(--teal-d));display:flex;align-items:center;justify-content:center}
.person .ph img{width:100%;height:100%;object-fit:cover;object-position:top}
.person .mono{font-family:'DM Serif Display';font-size:44px;color:#fff;opacity:.92}
.person h3{font-size:23px;margin:0}
.person .role{color:var(--teal-d);font-weight:600;font-size:13.5px;letter-spacing:.02em;margin:5px 0 12px}
.person p{font-size:14.5px;color:var(--muted);margin:0}
.person .ln{margin-top:14px;font-size:13.5px;font-weight:600;color:var(--blue)}
.adv-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:20px;margin-top:48px}
.adv{border:1px solid var(--line);border-radius:14px;padding:24px;background:#fff;text-align:center}
.adv .mono{width:64px;height:64px;border-radius:50%;margin:0 auto 16px;background:linear-gradient(150deg,var(--blue),var(--teal));color:#fff;display:flex;align-items:center;justify-content:center;font-family:'DM Serif Display';font-size:24px}
.adv h4{font-family:'DM Serif Display';font-size:18px;font-weight:400;margin:0}
.adv span{font-size:13px;color:var(--muted);display:block;margin-top:6px}

/* ============ NEWS / TIMELINE ============ */
.tl{margin-top:50px;display:grid;gap:18px}
.tlitem{display:grid;grid-template-columns:200px 1fr auto;gap:28px;align-items:center;border:1px solid var(--line);border-radius:16px;padding:28px 30px;background:#fff;transition:transform .4s var(--ease),border-color .4s,box-shadow .4s;text-decoration:none}
.tlitem:hover{transform:translateY(-4px);border-color:var(--teal);box-shadow:var(--shadow)}
.tlitem .when{font-size:13.5px;color:var(--muted)}
.tlitem .when b{display:block;font-family:'DM Serif Display';font-size:20px;color:var(--ink);font-weight:400}
.tlitem h3{font-size:21px;margin:0 0 6px}
.tlitem p{font-size:14.5px;color:var(--muted);margin:0;max-width:64ch}
.tlitem .badge{font-size:10.5px;font-weight:600;letter-spacing:.12em;text-transform:uppercase;color:var(--blue-d);background:var(--lblue);padding:7px 13px;border-radius:100px;white-space:nowrap}
.tlitem .badge.up{color:var(--teal-d);background:var(--lteal)}
.publist{margin-top:40px;display:grid;gap:14px}
.pub{display:grid;grid-template-columns:210px 1fr auto;gap:28px;align-items:start;border-bottom:1px solid var(--line);padding:24px 4px}
.pub .yr{font-family:'DM Serif Display';font-size:18px;color:var(--blue);line-height:1.3}
.pub h4{font-size:17px;margin:0 0 6px;font-family:'DM Sans';font-weight:600;color:var(--ink)}
.pub p{font-size:14px;color:var(--muted);margin:0}
.pub .st{font-size:11.5px;font-weight:600;text-transform:uppercase;letter-spacing:.08em;color:var(--teal-d);white-space:nowrap}

/* ============ CONTACT ============ */
.contact-grid{display:grid;grid-template-columns:1fr 1fr;gap:56px;margin-top:8px;align-items:start}
.cform{border:1px solid var(--line);border-radius:20px;padding:38px;background:#fff;box-shadow:var(--shadow)}
.formnote{border-radius:12px;padding:14px 18px;margin-bottom:22px;font-size:15px;font-weight:500;line-height:1.5}
.formnote.ok{background:rgba(14,138,122,.1);border:1px solid rgba(14,138,122,.4);color:var(--teal-d)}
.formnote.bad{background:rgba(190,40,40,.08);border:1px solid rgba(190,40,40,.35);color:#a32020}
.cform .fr{display:grid;grid-template-columns:1fr 1fr;gap:16px}
.field{margin-bottom:16px}
.field label{display:block;font-size:13px;font-weight:600;color:var(--navy);margin-bottom:7px}
.field input,.field select,.field textarea{width:100%;border:1px solid var(--line);border-radius:10px;padding:13px 15px;font-family:'DM Sans';font-size:15px;color:var(--ink);background:var(--mist);transition:border-color .25s,background .25s}
.field input:focus,.field select:focus,.field textarea:focus{outline:0;border-color:var(--teal);background:#fff}
.field textarea{min-height:130px;resize:vertical}
.cside .ibox{border:1px solid var(--line);border-radius:14px;padding:20px 22px;margin-bottom:14px;background:#fff;display:block;text-decoration:none;transition:border-color .3s,transform .3s}
.cside a.ibox:hover{border-color:var(--teal);transform:translateX(4px)}
.cside .ib-l{font-size:11.5px;font-weight:600;letter-spacing:.1em;text-transform:uppercase;color:var(--teal-d)}
.cside .ib-v{font-size:15px;color:var(--ink);margin-top:5px;font-weight:500}
.cside .ib-s{font-size:13px;color:var(--muted);margin-top:3px}

/* ============ ASSET SPOTLIGHT (pipeline) ============ */
.spot{background:linear-gradient(160deg,var(--navy),#0a1c38);color:#fff;position:relative;overflow:hidden}
.spot .split{display:grid;grid-template-columns:1fr 1fr;gap:60px;align-items:center}
.spot .tag{display:inline-block;font-size:11.5px;font-weight:600;letter-spacing:.16em;text-transform:uppercase;color:var(--teal);border:1px solid rgba(31,176,166,.4);padding:7px 13px;border-radius:100px}
.spot h2{font-size:clamp(30px,3.6vw,44px);color:#fff;margin-top:16px}
.spot h2 small{display:block;font-family:'DM Sans';font-size:15px;color:var(--teal);font-weight:500;margin-top:12px}
.spot p{color:#b3c2d6;font-size:16.5px;margin-top:20px;font-weight:300}
.spot .facts{display:grid;grid-template-columns:1fr 1fr;gap:14px;margin-top:28px}
.spot .fact{border:1px solid var(--line-2);border-radius:14px;padding:20px;background:rgba(255,255,255,.03)}
.spot .fact b{font-family:'DM Serif Display';font-size:16px;color:#fff;display:block;margin-bottom:6px;font-weight:400}
.spot .fact span{font-size:13.5px;color:#9fb0c6}
.spot-fig{border-radius:18px;overflow:hidden;border:1px solid var(--line-2);box-shadow:0 40px 80px -30px rgba(0,0,0,.6)}
.spot-fig img{width:100%;display:block}

/* metric cards (investors) */
.mcards{display:grid;grid-template-columns:repeat(4,1fr);gap:18px;margin-top:8px}
.mc{border:1px solid var(--line);border-radius:16px;padding:30px 26px;background:#fff}
.mc b{font-family:'DM Serif Display';font-size:40px;color:var(--blue);line-height:1;display:block}
.mc b span{color:var(--teal-d)}
.mc .k{font-size:13.5px;color:var(--muted);margin-top:12px}
.thesis{display:grid;grid-template-columns:repeat(3,1fr);gap:20px;margin-top:48px}
.tc{border:1px solid var(--line);border-radius:16px;padding:28px;background:#fff}
.tc .st{font-size:11.5px;font-weight:600;letter-spacing:.1em;text-transform:uppercase;color:var(--teal-d)}
.tc h3{font-size:20px;margin:12px 0 8px}
.tc p{font-size:14px;color:var(--muted);margin:0}
.tc .src{font-size:12px;color:var(--muted-2);margin-top:12px}

@media(max-width:960px){
  .people{grid-template-columns:1fr}.adv-grid{grid-template-columns:1fr}
  .contact-grid{grid-template-columns:1fr;gap:40px}
  .spot .split{grid-template-columns:1fr;gap:40px}
  .mcards{grid-template-columns:1fr 1fr}.thesis{grid-template-columns:1fr}
  .tlitem{grid-template-columns:1fr;gap:12px}
}
@media(max-width:560px){
  .person{grid-template-columns:1fr}.person .ph{width:120px;height:120px}
  .cform .fr{grid-template-columns:1fr}.mcards{grid-template-columns:1fr}
  .pub{grid-template-columns:1fr;gap:8px}
}

/* active nav state */
.navl a.cur::after{right:0}
.navl a.cur{opacity:1}
header.scrolled .navl a.cur{color:var(--blue)}

/* ============ FIX PASS — home/science feedback ============ */
/* CTA buttons: fix the white-on-white "white box" */
.cta .btn-light{background:#fff;color:var(--blue-d);font-weight:600;box-shadow:0 12px 30px -12px rgba(4,32,28,.4)}
.cta .btn-light:hover{color:var(--navy)}
.cta .btn-ghost{background:transparent;border:1.7px solid rgba(255,255,255,.7);color:#fff}
.cta .btn-ghost:hover{background:#fff;color:var(--teal-d);border-color:#fff}

/* Stat band — compact, no extra height */
.stats .stat{padding:40px 30px}
.stat b{font-size:36px;min-height:0;display:block;line-height:1.05}
.stat .k{margin-top:12px}

/* Home hero — make the flex container full-width so text aligns to the logo */
.hero .wrap{width:100%}

/* Hero — de-zoom so the full organelle reads, keep text clear on the left */
.hero-bg img,.hero-bg video{position:absolute;top:-4%;left:0;width:100%;height:108%;object-fit:cover;object-position:50% center;will-change:transform}
.phero .phero-bg{opacity:.92}

/* Clinical waterfall data-viz */
.waterfall{border:1px solid var(--line-2);border-radius:18px;background:rgba(255,255,255,.03);padding:30px 26px 22px;box-shadow:0 40px 80px -30px rgba(0,0,0,.6)}
.waterfall h4{font-family:'DM Sans';font-weight:600;font-size:14px;color:#fff;margin:0 0 4px;letter-spacing:.01em}
.waterfall .wsub{font-size:12.5px;color:#9fb0c6;margin-bottom:18px}
.waterfall svg{width:100%;height:auto;display:block}
.waterfall .wlegend{display:flex;gap:22px;margin-top:14px;font-size:12px;color:#b3c2d6}
.waterfall .wlegend span{display:flex;align-items:center;gap:7px}
.waterfall .wlegend i{width:11px;height:11px;border-radius:3px;display:inline-block}

/* ============ POLISH ============ */
::selection{background:rgba(31,176,166,.28);color:var(--ink)}
:focus-visible{outline:2px solid var(--teal);outline-offset:3px;border-radius:4px}
a,button{-webkit-tap-highlight-color:transparent}
.btn:active{transform:translateY(0) scale(.98)}
/* keep hero video from showing a hard edge while parallaxing */
.hero-bg,.phero-bg{backface-visibility:hidden}

/* ============ HERO VIDEO CROSSFADE ============ */
.hero-media{position:absolute;top:-4%;left:0;width:100%;height:108%;will-change:transform}
.hero-media video{position:absolute;inset:0;width:100%;height:100%;object-fit:cover;object-position:50% center;opacity:1;transition:opacity .9s linear}
.hero-media video.fade{opacity:0}

/* ============ LEGAL ============ */
.foot-legal a{color:#b3c2d6;transition:color .25s}
.foot-legal a:hover{color:#fff}
.legal{max-width:840px}
.legal .upd{font-size:13px;color:var(--muted-2);margin-bottom:30px;letter-spacing:.02em}
.legal h2{font-family:'DM Serif Display';font-size:25px;color:var(--ink);margin:38px 0 12px;font-weight:400}
.legal h3{font-size:16px;color:var(--ink);margin:22px 0 8px;font-weight:600;font-family:'DM Sans'}
.legal p{color:var(--muted-2);font-size:16px;line-height:1.8;margin-bottom:12px}
.legal ul{margin:10px 0 14px 22px}
.legal li{color:var(--muted-2);font-size:16px;line-height:1.75;margin-bottom:6px}
.legal a{color:var(--blue);font-weight:500}
.legal .note{background:var(--mist);border-left:3px solid var(--teal);border-radius:0 12px 12px 0;padding:18px 22px;font-size:14px;color:var(--muted-2);margin:28px 0}

/* ============ TUMOUR PHOTO CARDS (devstudio-style) ============ */
.photocards{display:grid;grid-template-columns:repeat(2,1fr);gap:22px;margin-top:54px}
.photocard{position:relative;aspect-ratio:16/10;border-radius:18px;overflow:hidden;box-shadow:var(--shadow);border:1px solid var(--line)}
.photocard img{width:100%;height:100%;object-fit:cover;transition:transform .7s var(--ease)}
.photocard:hover img{transform:scale(1.06)}
.photocard::after{content:"";position:absolute;inset:0;background:linear-gradient(180deg,rgba(10,22,40,.12) 28%,rgba(10,22,40,.6) 70%,rgba(10,22,40,.9) 100%)}
.photocard .pc-body{position:absolute;left:0;right:0;bottom:0;z-index:2;padding:28px}
.photocard .pc-badge{display:inline-block;font-size:10.5px;font-weight:600;letter-spacing:.12em;text-transform:uppercase;color:#fff;background:rgba(31,176,166,.85);padding:6px 12px;border-radius:100px}
.photocard h3{font-family:'DM Serif Display';font-weight:400;color:#fff;font-size:26px;margin:14px 0 5px;letter-spacing:-.01em}
.photocard p{color:#cfe0e8;font-size:13.5px;margin:0}
@media(max-width:680px){.photocards{grid-template-columns:1fr}}

/* scientist-over-science figure (home clinical) */
.sci-figure{border-radius:18px;overflow:hidden;border:1px solid var(--line-2);box-shadow:0 40px 80px -30px rgba(0,0,0,.6);position:relative}
.sci-figure img{width:100%;display:block}
.sci-figure .cap{position:absolute;left:0;right:0;bottom:0;padding:16px 22px;background:linear-gradient(transparent,rgba(8,18,36,.92));font-size:12.5px;color:#cfe0e8;z-index:2}

/* ============ LEADERSHIP FULL-WIDTH ROW ============ */
.leadsplit{display:grid;grid-template-columns:.82fr 1.18fr;gap:56px;align-items:center;margin-top:44px}
.leadphoto{border-radius:18px;overflow:hidden;border:1px solid var(--line);box-shadow:var(--shadow);background:var(--mist)}
.leadphoto img{width:100%;display:block}
.leadsplit .role{color:var(--teal-d);font-weight:600;margin-top:8px}
@media(max-width:880px){.leadsplit{grid-template-columns:1fr!important;gap:32px}.leadphoto{max-width:420px}}

/* ============ STUDY TABLE (pipeline, devstudio-style) ============ */
.studytable{margin-top:50px;border:1px solid var(--line);border-radius:18px;overflow:hidden;background:#fff;box-shadow:var(--shadow)}
.srow{display:grid;grid-template-columns:1fr 1.25fr 1fr .85fr 2.1fr;align-items:center;border-bottom:1px solid var(--line)}
.srow:last-child{border-bottom:0}
.srow.head{background:var(--navy)}
.srow.head div{font-size:11px;letter-spacing:.13em;text-transform:uppercase;font-weight:600;color:#aebccf;padding:17px 22px}
.srow .c{padding:22px 22px;font-size:14.5px;color:var(--ink);min-width:0}
.srow .study b{font-family:'DM Serif Display';font-size:16px;display:block;color:var(--ink);font-weight:400}
.srow .study em{font-style:normal;color:var(--blue);font-size:13px;font-weight:600}
.pstatus{display:inline-flex;align-items:center;gap:7px;font-size:12.5px;font-weight:600;padding:7px 13px;border-radius:100px;white-space:nowrap}
.pstatus::before{content:"";width:7px;height:7px;border-radius:50%;flex:0 0 7px}
.pstatus.done{background:var(--lblue);color:var(--blue-d)} .pstatus.done::before{background:var(--blue)}
.pstatus.active{background:var(--lteal);color:var(--teal-d)} .pstatus.active::before{background:var(--teal)}
.pstatus.planned{background:#fff3e0;color:#b8761a} .pstatus.planned::before{background:#e09a2e}
.phasedots{display:flex;gap:5px}
.phasedots i{width:20px;height:5px;border-radius:3px;background:var(--line);display:block}
.phasedots i.on{background:linear-gradient(90deg,var(--blue),var(--teal))}
.srow .pl{display:block;font-size:11.5px;color:var(--muted-2);margin-top:7px;font-weight:600}
.srow .notes{color:var(--muted);font-size:13.5px;line-height:1.5}
@media(max-width:900px){
  .srow,.srow.head{grid-template-columns:1.1fr 1fr 1fr}
  .srow .c:nth-child(4),.srow.head div:nth-child(4),.srow .notes,.srow.head div:nth-child(5){display:none}
}
@media(max-width:560px){.srow,.srow.head{grid-template-columns:1fr 1fr}.srow .c:nth-child(2),.srow.head div:nth-child(2){display:none}}

/* ============ AWWWARDS POLISH ============ */
/* scroll progress bar */
#progress{position:fixed;top:0;left:0;height:3px;width:0;z-index:200;background:linear-gradient(90deg,var(--blue),var(--teal));box-shadow:0 0 12px rgba(31,176,166,.6);transition:width .08s linear}
/* subtle film grain for filmic depth */
#grain{position:fixed;inset:0;z-index:300;pointer-events:none;opacity:.035;mix-blend-mode:overlay;
  background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='120' height='120'%3E%3Cfilter id='n'%3E%3CfeTurbulence type='fractalNoise' baseFrequency='0.9' numOctaves='2'/%3E%3C/filter%3E%3Crect width='100%25' height='100%25' filter='url(%23n)'/%3E%3C/svg%3E")}
/* count-up number lands cleanly */
.stat b span,.clstat b span,.mc b span{font-variant-numeric:tabular-nums}
/* page-load fade so first paint feels intentional */
body{animation:pageIn .7s var(--ease) both}
@keyframes pageIn{from{opacity:0}to{opacity:1}}
/* clip-reveal for key figures */
.figcard,.photocard,.cl-figure,.spot-fig,.sci-figure,.studytable,.ptable{clip-path:inset(0 0 0 0)}
.reveal .figcard,.figcard.reveal,.photocard.reveal,.cl-figure.reveal,.sci-figure.reveal{overflow:hidden}
@media(prefers-reduced-motion:reduce){#grain{display:none}body{animation:none}}

/* ============ METABOLISM DIAGRAM (Glycolysis vs OxPhos) ============ */
.metab{display:grid;grid-template-columns:1fr 1fr;background:#fff}
.metab-panel{padding:24px 18px 20px;display:flex;flex-direction:column;position:relative}
.metab-panel.gly{background:linear-gradient(180deg,#eef4fc,#e0ebfb)}
.metab-panel.oxphos{background:linear-gradient(180deg,#fdf2e9,#f8e4d1);border-left:1px solid rgba(13,34,64,.08)}
.mp-head b{font-family:'DM Serif Display';font-size:17px;color:var(--navy);display:block;line-height:1.12}
.mp-head span{font-size:10px;text-transform:uppercase;letter-spacing:.14em;color:var(--muted-2);font-weight:600}
.mp-flow{display:flex;flex-direction:column;align-items:center;gap:5px;margin:16px 0 14px;text-align:center}
.mp-flow .node{background:#fff;border:1px solid var(--line);border-radius:8px;padding:7px 12px;font-size:12px;font-weight:600;color:var(--ink);box-shadow:0 3px 8px -5px rgba(13,34,64,.45);line-height:1.25;max-width:100%}
.mp-flow .node.lead{background:var(--navy);color:#fff;border-color:transparent}
.mp-flow .arr{color:var(--muted-2);font-size:14px;line-height:.8}
.mp-flow .blocked{display:flex;align-items:center;gap:8px}
.lixblock{background:#e0556b;color:#fff;font-size:10.5px;font-weight:700;padding:5px 10px;border-radius:100px;letter-spacing:.02em;white-space:nowrap;box-shadow:0 4px 12px -4px rgba(224,85,107,.6)}
.mp-foot{margin-top:auto;display:flex;justify-content:space-between;align-items:center;gap:10px;border-top:1px solid rgba(13,34,64,.1);padding-top:14px}
.atpbadge{font-family:'DM Serif Display';font-size:14px;color:var(--navy)}
.atpbadge b{color:var(--teal-d);font-size:18px}
.o2{font-size:10px;color:var(--muted-2);font-weight:600;text-transform:uppercase;letter-spacing:.05em}
.metab-cap{padding:14px 20px;border-top:1px solid var(--line);font-size:12.5px;color:var(--muted);background:#fff;line-height:1.5}
@media(max-width:560px){.metab{grid-template-columns:1fr}.metab-panel.oxphos{border-left:0;border-top:1px solid rgba(13,34,64,.08)}}

/* two real diagram images, flush (no gap) */
.metab-img{display:grid;grid-template-columns:1fr 1fr;gap:0;background:#fff}
.metab-img img{width:100%;height:100%;object-fit:cover;display:block}
@media(max-width:560px){.metab-img{grid-template-columns:1fr}}