Publications
Bridges, H et al (2023)
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides https://www.science.org/doi/10.1126/science.ade3332
Willette R, et al (2021)
Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis
Rha S, et al (2020)
Phase 1 study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors
Izreig S, et al (2020)
Repression of LKB1 by miR-18~92 sensitizesMYC-dependent lymphoma to biguanide treatment [Cell Reports Medicine]
Son J, et al (2019) Metabolic reprogramming by the excessive AMPK activation exacerbates antigen-specific memory CD8+ T-cell differentiation after acute lymphocytic choriomeningitis [Immune Network]
Kim S-A, et al (2018) Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming [Aging]
Tsogbadrakh B, et al (2018) HL156A, a novel pharmacological agent with potent adenosine-monophosphate-activated protein kinase (AMPK) activator activity ameliorates renal fibrosis [PLOS ONE]
Son, MJ, et al (2018) A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming [Experimental and Molecular Medicine]
Lam T, et al (2017) New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways [Cancer Science]
Choi J, et al (2016) Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide, HL156A [Oncotarget]
Ju KD, et al (2016)HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosis [AJP-Renal Physiology]
Lee HS, et al (2016) AMP-activated protein kinase activator, HL156A reduces thioacetamide-induced liver fibrosis in mice and inhibits the activation of cultured hepatic stellate cells and macrophages [Intl Jour of Oncology]